Equine Diseases and Vaccinations: AAEP Core Vaccines


Vaccinations can protect your horse against diseases that can be serious or even fatal. There are many different types of vaccinations available, but most horses don’t need all of them. However, the American Association of Equine Practitioners recommends that all horses receive “core vaccinations” against eastern and western equine encephalomyelitis, West Nile virus, tetanus and rabies. Some horses (for example, those exposed to large numbers of horses at shows/events or traveling to an area experiencing an outbreak of a specific disease) may also need “non-core vaccinations,” such as those for equine herpesvirus, strangles and Potomac horse fever.

Eastern/Western Equine Encephalomyelitis

Eastern equine encephalomyelitis (EEE) and western equine encephalomyelitis (WEE), commonly referred to as “sleeping sickness,” are viral diseases spread primarily by mosquitoes. Symptoms include fever, lethargy and various neurological abnormalities, including incoordination, vision deficits, circling, paralysis and convulsions. Death occurs in up to 50 percent of WEE cases and 90 percent of EEE cases, usually within two to three days.

West Nile Virus

West Nile virus infection (WNV) is also spread by mosquitoes. Wild birds are an important source of the virus and often show no signs of disease. The symptoms of WNV are quite variable. In general, they resemble those of EEE/WEE, but may also include colic, lameness and appetite loss. Most infected horses show some incoordination and paralysis. Muscle tremors of the face or neck muscles often occur, along with weakness or paralysis of the muscles of the face and tongue. The disease can cause behavioral abnormalities ranging from nervousness to hyperexcitability. Death occurs in about 30 to 40 percent of the cases.


Tetanus is caused by a toxin produced by Clostridium tetani, bacteria found in the intestinal tract and soil. Infection occurs when the bacteria enter a wound that provides a suitable environment for growth, such as a puncture wound. The likelihood of infection is not related to the severity of the wound. Initial symptoms include muscle stiffness in the jaw, neck, hind legs and the area of the infected wound. More extensive stiffness, along with muscle spasms and hyperexcitability in response to external stimuli, occurs within 24 hours. A horse with tetanus has a characteristic facial expression: flared nostrils, tensed lips pulled back, prolapsed third eyelid and erect ears. Eating becomes difficult. The horse resists movement and adopts a “sawhorse” stance, with front legs extended forward and rear legs extended back. Relatively minor motions or sounds can trigger violent muscle contractions. Increased heart rate, arrhythmias (abnormalities of the heartbeat) and high blood pressure also occur. Involvement of the muscles of respiration can lead to death. The survival rate for tetanus averages about 20 percent.

Horse Vaccine


Rabies is a viral disease that can affect any mammal. It occurs when a rabid animal (usually a skunk, raccoon, fox or bat) bites the horse and virus-containing saliva enters the bloodstream. The wound often occurs on the muzzle or face (because the horse extends its muzzle to investigate the odd behavior of the rabid animal), but can occur anywhere on the body. The symptoms of rabies, which are caused by encephalitis (inflammation of the brain), include behavioral changes and unexplained paralysis. The affected horse may become hyperexcitable, vicious and unpredictable, attacking other animals, humans, or even itself. In some cases, the major symptom is paralysis of the throat and jaw muscles, which rapidly progresses to the rest of the body. These horses may show no signs of aggression. The incidence of rabies is relatively low in horses, but the disease is invariably fatal.

DIY or Not?

Taking care of vaccinations isn’t just a matter of picking up some vaccine at the feed or supply store and getting it into your horse. Even if you know how to give an intramuscular injection, there are some good reasons why you shouldn’t take a do-it-yourself approach to your horse’s vaccination program:

  • The right choice. Vaccines for the same disease can have different formulations, depending on how they’re prepared. The local supply store vaccine may not be the best formulation for your horse.
  • Quality control. If the vaccine hasn’t been shipped and stored under proper conditions, the protection it provides may be inadequate.
  • Program planning. The accompanying tables are guidelines only. Your veterinarian can assess your horse’s needs and recommend the best vaccination schedule.
  • Peace of mind. Your veterinarian has the training and experience to vaccinate your horse and treat adverse reactions, which, although rare, can be life-threatening.


  1. Galadriel,
    The reason a veterinarian should be the one to vaccinate a horse is because he has been educated in more than just how to administer the vaccine. If one of your horses had reacted to a vaccine, would you have recognized the first warning sign? Have you been educated in the complex studies of veterinary medicine that allow you to recognize the first symptoms of an allergic reaction and aid in ceasing any further reactions that could be fatal to the horse?
    It concerns me greatly that you believe your veterinarian would laugh at you for asking him to administer vaccines, as a vet should know that there is always a potential for something to go wrong when vaccinating an animal, and he is the one that has been trained to handle a situation like this. I would not trust a vet like that to treat my horses.

  2. I guess I missed the reading of the Table of scheduled vaccines. These were the questions I missed on the exam. I didn’t know there were any Tables to study. Where are they?

  3. I have always done all my own vaccines, but if it is your first time doing it, I would have your vet show you how, or ask a friend that knows.

  4. I agree with Betty. Don’t see any listing of the Table of scheduled vaccines, not even in the extra credit. I too missed questions on the quiz and just received “incorrect” instead of an answer.

  5. Missed a question on the quiz about which horse needed non-core vaccinations. If you are showing at that many shows, there are a number of extra vaccinations you would need to give, as per the show guidelines.
    Not sure what they were looking for…


Please enter your comment!
Please enter your name here